Guide
Best Supplements for Libido: Evidence-Based Options for Men and Women (2026)
By SupplementList Editorial Team • 2026-04-28
Disclaimer: This guide is for educational purposes only and does not constitute medical advice. Low libido can be caused by hormonal imbalances, medications, relationship factors, or underlying health conditions. Consult a healthcare provider before using supplements, especially if you are on medications or have a chronic health condition. Supplements are not FDA-approved treatments for sexual dysfunction.
What Actually Affects Libido
Sexual desire is regulated by a complex interplay of hormones (testosterone, estrogen, DHEA, cortisol), neurotransmitters (dopamine, serotonin), nitric oxide production (for blood flow), and psychological factors (stress, sleep, relationship quality). In both men and women, the most common addressable causes of low libido are: low testosterone or DHEA, high cortisol from chronic stress, nutrient deficiencies (zinc, vitamin D), poor sleep, and excess prolactin. Supplements work by supporting these systems — they cannot override psychological factors or medication side effects, but they can meaningfully address physiological contributors.
Top Evidence-Based Libido Supplements
1. Maca Root
Maca (Lepidium meyenii) is the most extensively studied botanical for libido in both men and women. Unlike testosterone boosters, maca's mechanism isn't fully understood — it doesn't raise testosterone but appears to influence hypothalamic-pituitary signaling and energy metabolism. A 2010 systematic review of 4 RCTs found maca consistently improved sexual dysfunction and libido in healthy adults and those experiencing antidepressant-induced sexual dysfunction (Shin et al., 2010). A 2008 double-blind RCT found maca extract (3g/day) significantly improved sexual desire vs. placebo at 8 and 12 weeks in healthy adult men. Dose: 1.5–3g/day; 12 weeks for full effect. Black maca is most studied for libido; yellow maca is more commonly available. Well-tolerated; rare GI discomfort at high doses.
2. Ashwagandha (KSM-66)
Ashwagandha's libido benefit is primarily via cortisol reduction and testosterone support. Chronic cortisol elevation suppresses LH (luteinizing hormone), reducing testosterone production — ashwagandha corrects this by normalizing the HPA axis. A 2019 RCT found women taking KSM-66 ashwagandha (300 mg twice daily) showed significant improvements in sexual function scores (arousal, lubrication, orgasm, satisfaction) vs. placebo (Dongre et al., 2015). In men, a 2010 RCT found KSM-66 (600 mg/day, 12 weeks) raised testosterone by 14.7% and improved sexual health scores. Best for libido suppressed by chronic stress or elevated cortisol. Dose: 300–600 mg KSM-66 extract daily.
3. Tongkat Ali (Eurycoma longifolia)
Tongkat Ali is a Southeast Asian herb that appears to work by reducing sex hormone-binding globulin (SHBG), which binds testosterone and renders it unavailable — lower SHBG means more free (biologically active) testosterone. A 2012 pilot study found Tongkat Ali extract (200 mg/day, 4 weeks) significantly improved testosterone levels and sexual well-being in men with late-onset hypogonadism (Tambi et al., 2012). A 2014 RCT found 300 mg/day improved muscle strength and libido in recreational athletes. Quality varies significantly across products — look for standardized extracts (1:200 water extract, minimum 22% eurypeptides). Dose: 200–400 mg/day; cycling (5 days on, 2 off) is commonly recommended.
4. Shilajit
Shilajit is a mineral-rich resin from Himalayan rocks with evidence for testosterone support and mitochondrial energy production. It contains fulvic acid and dibenzo-alpha-pyrones that support CoQ10 function in cells. A 2015 clinical study found shilajit (250 mg twice daily, 90 days) significantly raised total testosterone (by ~23%), free testosterone (by ~19%), and DHEA vs. placebo in healthy male volunteers aged 45–55 (Pandit et al., 2015). Well-tolerated; standardize on 50% fulvic acid content for quality. Dose: 250–500 mg/day with warm water or milk. Pair with ashwagandha or zinc for synergistic testosterone support.
5. L-Arginine (for Blood Flow)
L-arginine is a precursor to nitric oxide (NO), which dilates blood vessels — improved genital blood flow is essential for arousal and physical sexual response in both sexes. Studies show oral l-arginine improves erectile function in men with mild-to-moderate ED and may improve arousal response in women. A meta-analysis found l-arginine supplementation (3–6g/day) significantly improved erectile function scores vs. placebo (Rhim et al., 2019). Dose: 3–6g/day; best taken 30–60 minutes before sexual activity. Most effective in combination with pycnogenol (maritime pine bark) — the combination has stronger RCT evidence than either alone.
Foundational Nutrients for Sexual Health
Before adding targeted botanicals, address common deficiencies: Zinc — essential for testosterone synthesis; deficiency (common in athletes and vegans) directly suppresses testosterone. Vitamin D — functions as a steroid hormone prohormone; low vitamin D correlates with low testosterone in multiple studies. Magnesium — binds and competes with SHBG, increasing free testosterone; also reduces stress hormones that suppress libido.